PCED1A

Across TCGA pan-cancer cohorts, PCED1A RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PCED1A data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PCED1A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PCED1A expression acts as an unfavorable survival marker, although some lineages such as PAAD and SKCM show a favorable association.

COAD, KIRC, and LIHC are the cancer types where PCED1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.736	0.861	<.001	133	view →
KIRC	DFS	Median	II,III,IV	0.386	0.627	<.001	110	view →
LIHC	DFS	Median	All	0.465	0.618	<.001	84	view →
LUAD	DFS	Quartile	All	0.379	0.541	.005	40	view →
KICH	OS	Median	II,III,IV	0.757	1.000	.005	35	view →
PAAD	OS	Median	All	0.509	0.265	.003	33	view →
SKCM	DFS	Tertile	III,IV	0.591	0.313	<.001	29	view →
BLCA	OS	Median	II,III,IV	0.773	0.642	<.001	26	view →
MESO	DFS	Tertile	All	0.211	0.742	.001	24	view →
PRAD	DFS	Median	All	0.678	0.915	<.001	18	view →
READ	OS	Quartile	III,IV	0.833	0.427	.001	17	view →
ESCA	DFS	Quartile	II,III,IV	1.000	0.209	.006	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PCED1A–COAD (OS)

Open the COAD breakdown →