PCDHGC5

Across TCGA cell cohorts, PCDHGC5 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGC5-associated genes across cancer lineages are RGR, CLRN1, and SH3GL2. Each is linked with PCDHGC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGC5-to-partner and partner-to-PCDHGC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RGR grouped by PCDHGC5-low versus PCDHGC5-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGC5→partner) and Y-score (partner→PCDHGC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RGR →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	CLRN1 →	+0.033	+5.087	<.001	.004	3	1
LARGE_INTESTINE	SH3GL2 →	+1.692	+3.667	<.001	<.001	3	1
LARGE_INTESTINE	ULBP3 →	+0.890	+3.064	.005	.009	3	1
LARGE_INTESTINE	FAM124A →	+0.846	+3.295	<.001	.006	3	1
LARGE_INTESTINE	FAM153B →	+0.393	+2.841	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

RGR by PCDHGC5 expression — URINARY_TRACT

Explore this box plot interactively →