PCDHGC4

Across TCGA patient cohorts, PCDHGC4 mutation is significantly associated with the RNA expression of many other genes, with 4,284 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGC4-associated genes across cancer lineages are TIMM21, MMP12, and UQCRC1. Each is linked with PCDHGC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHGC4-to-partner and partner-to-PCDHGC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM21 grouped by PCDHGC4-low versus PCDHGC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGC4→partner) and Y-score (partner→PCDHGC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMM21 →	+0.529	+2.061	<.001	<.001	3	4
UCEC	MMP12 →	+0.933	+2.436	.002	.001	3	3
STAD	UQCRC1 →	+0.653	+3.203	<.001	.009	3	3
SKCM	RPF1 →	+0.457	+2.508	.009	.001	3	3
STAD	UBR7 →	+0.595	+3.203	<.001	.009	3	3
UCEC	EIF2S1 →	+0.560	+2.082	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,284 associations by consensus.

TIMM21 by PCDHGC4 expression — UCEC

Explore this box plot interactively →