PCDHGB7

Across TCGA pan-cancer cohorts, PCDHGB7 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PCDHGB7’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PCDHGB7 RNA is repressed in tumor relative to normal tissue. In most cancer types PCDHGB7 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KICH, and UCEC are the cancer types where PCDHGB7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCDHGB7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−1.500	<.001	11	view →
KICH	Male	All	−1.436	<.001	10	view →
UCEC	All	II,III,IV	−1.848	<.001	8	view →
LUAD	Female	III,IV	−1.552	<.001	8	view →
HNSC	Male	III,IV	−0.978	.003	8	view →
KIRC	Male	II,III,IV	+1.017	<.001	7	view →
LUSC	Female	II,III,IV	−1.957	<.001	6	view →
BRCA	All	III,IV	−1.245	<.001	6	view →
COAD	All	II,III,IV	−0.523	<.001	6	view →
STAD	All	All	−0.658	.029	3	view →
READ	Female	All	−1.393	.023	2	view →
CHOL	All	All	+0.893	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PCDHGB7–BLCA

Open the BLCA breakdown →