PCDHGB4

Across TCGA patient cohorts, PCDHGB4 mutation is significantly associated with the RNA expression of many other genes, with 5,148 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGB4-associated genes across cancer lineages are NCAPG, CEP55, and CDCA2. Each is linked with PCDHGB4 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHGB4-to-partner and partner-to-PCDHGB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPG grouped by PCDHGB4-low versus PCDHGB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGB4→partner) and Y-score (partner→PCDHGB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPG →	+0.720	+2.403	<.001	<.001	3	5
UCEC	CEP55 →	+0.597	+1.415	<.001	.002	3	5
UCEC	CDCA2 →	+0.834	+1.765	<.001	<.001	3	4
SKCM	ARHGAP11A →	+0.800	+1.892	<.001	.004	3	4
UCEC	TXNL1 →	+0.437	+1.765	<.001	<.001	3	4
UCEC	WDR76 →	+0.800	+2.191	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,148 associations by consensus.

NCAPG by PCDHGB4 expression — UCEC

Explore this box plot interactively →