PCDHGB4

Across TCGA pan-cancer cohorts, PCDHGB4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PCDHGB4’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where PCDHGB4 RNA is repressed in tumor relative to normal tissue. In most cancer types PCDHGB4 is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.

UCEC, KICH, and LUSC are the cancer types where PCDHGB4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCDHGB4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	−0.881	<.001	8	view →
KICH	Male	IV	−1.030	<.001	7	view →
LUSC	Female	II,III,IV	−0.900	<.001	7	view →
KIRC	Male	II,III,IV	−0.707	<.001	7	view →
BRCA	All	All	−0.349	<.001	6	view →
STAD	Female	All	−0.442	.003	4	view →
ESCA	All	II,III,IV	−0.470	.046	2	view →
KIRP	All	All	−0.447	.027	2	view →
LIHC	Male	III,IV	−0.300	.033	1	view →
COAD	Female	III,IV	−0.260	.002	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PCDHGB4–UCEC

Open the UCEC breakdown →