PCDHGB4

Across TCGA cell cohorts, PCDHGB4 mutation is significantly associated with the RNA expression of many other genes, with 159 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGB4-associated genes across cancer lineages are MEIKIN, OR8K3, and OR2T29. Each is linked with PCDHGB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGB4-to-partner and partner-to-PCDHGB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEIKIN grouped by PCDHGB4-low versus PCDHGB4-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGB4→partner) and Y-score (partner→PCDHGB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MEIKIN →	+0.476	+5.087	<.001	.004	3	2
URINARY_TRACT	OR8K3 →	+0.033	+5.087	<.001	.004	3	2
OESOPHAGUS	OR2T29 →	+0.116	+4.906	<.001	.006	3	2
LUNG_SCLC	SHCBP1L →	+0.291	+3.817	.001	.004	3	2
SKIN	COL6A5 →	+0.190	+4.145	<.001	.001	3	2
URINARY_TRACT	XAGE5 →	+0.353	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 159 associations by consensus.

MEIKIN by PCDHGB4 expression — URINARY_TRACT

Explore this box plot interactively →