PCDHGB2

Across TCGA patient cohorts, PCDHGB2 mutation is significantly associated with the RNA expression of many other genes, with 4,992 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGB2-associated genes across cancer lineages are ATP5F1B, SRIP1, and MTMR4. Each is linked with PCDHGB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHGB2-to-partner and partner-to-PCDHGB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5F1B grouped by PCDHGB2-low versus PCDHGB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGB2→partner) and Y-score (partner→PCDHGB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP5F1B →	+0.355	+1.593	.006	.002	3	5
READ	SRIP1 →	+0.272	+4.315	<.001	.002	3	4
LUSC	MTMR4 →	+0.428	+3.758	.001	<.001	3	4
LUSC	NSD2 →	+0.428	+2.240	.006	.005	3	4
LUSC	HIRIP3 →	+0.472	+3.596	<.001	.001	3	4
LUAD	DCAF16 →	+0.510	+4.169	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,992 associations by consensus.

ATP5F1B by PCDHGB2 expression — UCEC

Explore this box plot interactively →