PCDHGA7

Across TCGA patient cohorts, PCDHGA7 mutation is significantly associated with the RNA expression of many other genes, with 2,890 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA7-associated genes across cancer lineages are NDUFA6, UQCRH, and SRSF4. Each is linked with PCDHGA7 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHGA7-to-partner and partner-to-PCDHGA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA6 grouped by PCDHGA7-low versus PCDHGA7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA7→partner) and Y-score (partner→PCDHGA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFA6 →	+0.423	+1.936	<.001	<.001	3	5
SKCM	UQCRH →	+0.406	+2.373	<.001	<.001	3	4
UCEC	SRSF4 →	+0.281	+1.584	.001	<.001	3	4
UCEC	CKS2 →	+0.412	+1.801	.002	.001	3	4
BRCA	RNU6-660P →	+0.158	+4.231	<.001	.007	3	3
STAD	LARP1B →	+0.516	+3.472	<.001	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,890 associations by consensus.

NDUFA6 by PCDHGA7 expression — UCEC

Explore this box plot interactively →