PCDHGA7

Across TCGA patient cohorts, PCDHGA7 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA7-associated genes across cancer lineages are p21, Annexin-1, and ATM. Each is linked with PCDHGA7 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHGA7-to-partner and partner-to-PCDHGA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by PCDHGA7-low versus PCDHGA7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA7→partner) and Y-score (partner→PCDHGA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.133	+2.000	.014	.009	3	3
UCEC	Annexin-1 →	+0.514	+2.157	<.001	<.001	3	2
UCEC	ATM →	-0.415	-2.074	.001	.004	3	2
SKCM	ACVRL1 →	+0.120	+1.999	.013	.002	3	2
COAD	4E-BP1 →	+0.199	+2.593	.030	.006	3	2
LUSC	MIG-6 →	+0.209	+2.816	.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

p21 by PCDHGA7 expression — UCEC

Explore this box plot interactively →