PCDHGA7

Across TCGA cell cohorts, PCDHGA7 mutation is significantly associated with the mutation status of many other genes, with 5,688 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGA7-associated genes across cancer lineages are BRWD1, AGAP2, and BOD1L1. Each is linked with PCDHGA7 in more than 5 cancer types. Because this analysis shows association rather than direction, both PCDHGA7-to-partner and partner-to-PCDHGA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRWD1 grouped by PCDHGA7-low versus PCDHGA7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA7→partner) and Y-score (partner→PCDHGA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BRWD1 →	+2.946	+2.862	.001	.001	1	6
OVARY	AGAP2 →	+4.930	+3.977	.001	.001	1	5
OVARY	BOD1L1 →	+2.538	+3.347	.005	.005	1	5
LUNG_SCLC	WDR62 →	+4.307	+4.307	.001	.001	1	5
LUNG_SCLC	MAST1 →	+2.985	+3.562	.008	.008	1	5
BLOOD_Leukemia	DSP →	+2.472	+2.741	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,688 associations by consensus.

BRWD1 by PCDHGA7 expression — BLOOD_Leukemia

Explore this box plot interactively →