PCDHGA4

Across TCGA cell cohorts, PCDHGA4 mutation is significantly associated with the RNA expression of many other genes, with 210 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGA4-associated genes across cancer lineages are GPX5, MYOD1, and KHDC3L. Each is linked with PCDHGA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGA4-to-partner and partner-to-PCDHGA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPX5 grouped by PCDHGA4-low versus PCDHGA4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA4→partner) and Y-score (partner→PCDHGA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPX5 →	+0.006	+4.017	<.001	.007	3	2
BLOOD_Lymphoma	MYOD1 →	+0.020	+5.169	<.001	.001	3	2
OESOPHAGUS	KHDC3L →	+0.069	+4.017	<.001	.007	3	1
OESOPHAGUS	GLYATL3 →	+0.090	+4.017	<.001	.007	3	1
OVARY	PAX7 →	+0.776	+4.044	<.001	.003	2	2
LARGE_INTESTINE	GCAT →	+1.094	+3.169	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 210 associations by consensus.

GPX5 by PCDHGA4 expression — OESOPHAGUS

Explore this box plot interactively →