PCDHGA12

Across TCGA cell cohorts, PCDHGA12 mutation is significantly associated with the RNA expression of many other genes, with 1,159 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGA12-associated genes across cancer lineages are TMED2, KHDC3L, and OR52E2. Each is linked with PCDHGA12 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHGA12-to-partner and partner-to-PCDHGA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMED2 grouped by PCDHGA12-low versus PCDHGA12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA12→partner) and Y-score (partner→PCDHGA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMED2 →	+0.459	+3.321	.001	.003	3	3
OESOPHAGUS	KHDC3L →	+0.069	+4.017	<.001	.007	3	2
LUNG_NSCLC_LUAD	OR52E2 →	+0.140	+3.150	.004	.006	3	2
OVARY	TAS2R39 →	+0.024	+3.990	<.001	.003	3	2
LARGE_INTESTINE	HMGXB4 →	+0.641	+2.628	<.001	.002	3	2
LARGE_INTESTINE	CEP76 →	+0.597	+2.628	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,159 associations by consensus.

TMED2 by PCDHGA12 expression — LARGE_INTESTINE

Explore this box plot interactively →