PCDHGA11

Across TCGA cell cohorts, PCDHGA11 mutation is significantly associated with the RNA expression of many other genes, with 526 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGA11-associated genes across cancer lineages are GHSR, GLYATL3, and MFRP. Each is linked with PCDHGA11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGA11-to-partner and partner-to-PCDHGA11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHSR grouped by PCDHGA11-low versus PCDHGA11-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA11→partner) and Y-score (partner→PCDHGA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GHSR →	+0.042	+4.017	<.001	.007	3	1
OESOPHAGUS	GLYATL3 →	+0.090	+4.017	<.001	.007	3	1
OESOPHAGUS	MFRP →	+0.011	+4.392	.003	.003	3	1
LUNG_SCLC	PRR23B →	+0.005	+4.643	<.001	.004	3	1
LUNG_SCLC	OR7E24 →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	HLA-DQA2 →	+0.222	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 526 associations by consensus.

GHSR by PCDHGA11 expression — OESOPHAGUS

Explore this box plot interactively →