PCDHGA10

Across TCGA patient cohorts, PCDHGA10 mutation is significantly associated with the RNA expression of many other genes, with 6,395 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA10-associated genes across cancer lineages are TIMM21, BRD2, and DRG1. Each is linked with PCDHGA10 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHGA10-to-partner and partner-to-PCDHGA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM21 grouped by PCDHGA10-low versus PCDHGA10-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA10→partner) and Y-score (partner→PCDHGA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TIMM21 →	+0.681	+3.220	<.001	.009	3	5
SKCM	BRD2 →	+0.441	+2.826	.004	.001	3	4
UCEC	DRG1 →	+0.240	+1.604	.005	<.001	3	4
COAD	MTFP1 →	+0.641	+3.605	<.001	.001	3	4
UCEC	MRPL46 →	+0.354	+2.204	<.001	<.001	3	4
SKCM	MED31 →	+0.534	+2.851	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,395 associations by consensus.

TIMM21 by PCDHGA10 expression — STAD

Explore this box plot interactively →