PCDHGA10

Across TCGA pan-cancer cohorts, PCDHGA10 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PCDHGA10 data layer compared with 8 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PCDHGA10 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PCDHGA10 expression acts as an unfavorable survival marker, although some lineages such as KIRC and PCPG show a favorable association.

CESC, HNSC, and LUSC are the cancer types where PCDHGA10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	All	0.398	0.640	<.001	82	view →
HNSC	OS	Quartile	III,IV	0.291	0.729	.002	57	view →
LUSC	OS	Tertile	All	0.273	0.502	<.001	56	view →
ACC	DFS	Median	All	0.428	0.794	.001	43	view →
STAD	OS	Median	II,III,IV	0.405	0.713	.008	40	view →
KIRC	DFS	Tertile	IV	0.524	0.223	.010	34	view →
KIRP	DFS	Tertile	III,IV	0.211	0.940	.008	31	view →
BLCA	DFS	Quartile	III,IV	0.378	0.659	.016	15	view →
PCPG	DFS	Median	All	0.983	0.852	.001	14	view →
READ	DFS	Median	III,IV	0.288	0.807	<.001	14	view →
PRAD	DFS	Median	All	0.914	0.853	.021	8	view →
COAD	OS	Quartile	All	0.824	0.941	.031	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

PCDHGA10–CESC (DFS)

Open the CESC breakdown →