PCDHGA10

Across TCGA patient cohorts, PCDHGA10 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA10-associated genes across cancer lineages are Notch1, Cyclin-B1, and Cyclin-E2. Each is linked with PCDHGA10 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHGA10-to-partner and partner-to-PCDHGA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PCDHGA10-low versus PCDHGA10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA10→partner) and Y-score (partner→PCDHGA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.157	+1.676	<.001	.005	3	4
UCEC	Cyclin-B1 →	+0.644	+3.999	<.001	<.001	3	2
STAD	Cyclin-E2 →	+0.199	+3.021	.004	.018	1	4
COAD	eIF4E →	+0.346	+2.347	<.001	.019	1	4
UCEC	FoxM1 →	+0.184	+1.378	.017	.008	3	2
UCEC	PDCD4 →	-0.544	-2.502	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Notch1 by PCDHGA10 expression — UCEC

Explore this box plot interactively →