PCDHGA10

Across TCGA cell cohorts, PCDHGA10 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGA10-associated genes across cancer lineages are SLC22A8, TRIM60, and LYPD2. Each is linked with PCDHGA10 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGA10-to-partner and partner-to-PCDHGA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC22A8 grouped by PCDHGA10-low versus PCDHGA10-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA10→partner) and Y-score (partner→PCDHGA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC22A8 →	+0.861	+4.044	<.001	.009	3	1
LUNG_SCLC	TRIM60 →	+0.005	+4.643	<.001	.004	3	1
LUNG_SCLC	LYPD2 →	+0.705	+4.269	<.001	.005	3	1
LUNG_SCLC	C1orf146 →	+0.097	+4.044	<.001	.009	3	1
LUNG_SCLC	OR2B3 →	+0.017	+4.643	<.001	.004	3	1
LUNG_SCLC	USP17L4 →	+0.035	+4.523	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

SLC22A8 by PCDHGA10 expression — LUNG_SCLC

Explore this box plot interactively →