Across TCGA patient cohorts, PCDHGA1 mutation is significantly associated with the RNA expression of many other genes, with 5,027 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGA1-associated genes across cancer lineages are CDCA2, LINC00865, and SLC35B1. Each is linked with PCDHGA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHGA1-to-partner and partner-to-PCDHGA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGA1→partner) and Y-score (partner→PCDHGA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CDCA2 →	+0.724	+2.887	<.001	<.001	3	4
COAD	LINC00865 →	-0.358	-2.880	.002	.001	3	4
UCEC	SLC35B1 →	+0.338	+1.523	<.001	<.001	3	4
UCEC	PSMC3IP →	+0.490	+1.860	<.001	<.001	3	4
UCEC	TMEM62 →	+0.378	+1.343	.003	.003	3	4
UCEC	C15orf61 →	+0.356	+2.169	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,027 associations by consensus.

Exploration

PCDHGA1 survival (RNA) · tumor vs normal (RNA) · all PCDHGA1 data types