PCDHB7

Across TCGA patient cohorts, PCDHB7 mutation is significantly associated with the RNA expression of many other genes, with 6,633 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB7-associated genes across cancer lineages are PRMT5, PGAM5, and DSCC1. Each is linked with PCDHB7 in more than 5 cancer types. Because this analysis shows association rather than direction, both PCDHB7-to-partner and partner-to-PCDHB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRMT5 grouped by PCDHB7-low versus PCDHB7-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB7→partner) and Y-score (partner→PCDHB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PRMT5 →	+0.526	+3.525	.001	.002	3	6
CESC	PGAM5 →	+0.667	+3.219	<.001	.009	3	5
LUAD	DSCC1 →	+0.679	+2.115	<.001	<.001	3	5
CESC	WDR12 →	+0.535	+3.199	.002	.009	3	5
CESC	PHAX →	+0.514	+3.219	<.001	.009	3	5
UCEC	KMT5A →	+0.347	+1.673	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,633 associations by consensus.

PRMT5 by PCDHB7 expression — STAD

Explore this box plot interactively →