PCDHB5

Across TCGA patient cohorts, PCDHB5 mutation is significantly associated with the total protein of many other genes, with 87 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB5-associated genes across cancer lineages are 4E-BP1, Caspase-7-cleavedD198, and C-Raf. Each is linked with PCDHB5 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHB5-to-partner and partner-to-PCDHB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PCDHB5-low versus PCDHB5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB5→partner) and Y-score (partner→PCDHB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.365	+2.736	<.001	<.001	3	5
COAD	Caspase-7-cleavedD198 →	+0.880	+1.671	<.001	.006	3	4
UCEC	C-Raf →	+0.183	+1.447	<.001	.002	3	4
UCEC	eIF4E →	+0.177	+1.861	.002	.004	3	4
UCEC	p70-S6K →	+0.143	+1.299	.008	.004	3	4
UCEC	STAT3_pY705 →	-0.399	-2.584	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

4E-BP1 by PCDHB5 expression — UCEC

Explore this box plot interactively →