PCDHB5

Across TCGA cell cohorts, PCDHB5 mutation is significantly associated with the RNA expression of many other genes, with 594 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHB5-associated genes across cancer lineages are TRIM64B, G6PC, and VRTN. Each is linked with PCDHB5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHB5-to-partner and partner-to-PCDHB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM64B grouped by PCDHB5-low versus PCDHB5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB5→partner) and Y-score (partner→PCDHB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TRIM64B →	+0.025	+3.029	<.001	.003	3	3
BLOOD_Myeloma	G6PC →	+0.023	+3.906	<.001	.009	3	2
BLOOD_Myeloma	VRTN →	+0.024	+4.285	<.001	.003	3	2
LARGE_INTESTINE	FCGRT →	-2.278	-3.321	<.001	.003	3	2
LARGE_INTESTINE	KRT23 →	-2.433	-2.072	.004	.008	3	2
SKIN	RNF128 →	-1.926	-3.278	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 594 associations by consensus.

TRIM64B by PCDHB5 expression — LUNG_SCLC

Explore this box plot interactively →