PCDHB3

Across TCGA patient cohorts, PCDHB3 mutation is significantly associated with the RNA expression of many other genes, with 5,622 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB3-associated genes across cancer lineages are SMC3, MRM3, and ZNF57. Each is linked with PCDHB3 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHB3-to-partner and partner-to-PCDHB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMC3 grouped by PCDHB3-low versus PCDHB3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB3→partner) and Y-score (partner→PCDHB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SMC3 →	+0.634	+3.338	<.001	.004	3	5
UCEC	MRM3 →	+0.443	+1.850	<.001	<.001	3	5
UCEC	ZNF57 →	+0.299	+1.356	<.001	.003	3	5
UCEC	ZWINT →	+0.664	+1.514	<.001	<.001	3	5
LUSC	LRRK1 →	-0.427	-3.665	.006	.001	3	4
HNSC	WDR74 →	+0.484	+3.347	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,622 associations by consensus.

SMC3 by PCDHB3 expression — STAD

Explore this box plot interactively →