PCDHB14

Across TCGA patient cohorts, PCDHB14 mutation is significantly associated with the RNA expression of many other genes, with 5,392 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB14-associated genes across cancer lineages are BCCIP, YWHAE, and MRPS27. Each is linked with PCDHB14 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHB14-to-partner and partner-to-PCDHB14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCCIP grouped by PCDHB14-low versus PCDHB14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB14→partner) and Y-score (partner→PCDHB14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BCCIP →	+0.433	+2.111	<.001	<.001	3	4
UCEC	YWHAE →	+0.311	+2.071	<.001	<.001	3	4
UCEC	MRPS27 →	+0.362	+2.108	.001	.002	3	4
UCEC	RPF1 →	+0.317	+1.370	.006	.007	3	4
UCEC	TARDBP →	+0.256	+1.523	.002	<.001	3	4
UCEC	HJURP →	+0.477	+1.668	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,392 associations by consensus.

BCCIP by PCDHB14 expression — UCEC

Explore this box plot interactively →