PCDHB12

Across TCGA patient cohorts, PCDHB12 mutation is significantly associated with the RNA expression of many other genes, with 6,923 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB12-associated genes across cancer lineages are SLC3A2, PSPC1, and MYO19. Each is linked with PCDHB12 in more than 5 cancer types. Because this analysis shows association rather than direction, both PCDHB12-to-partner and partner-to-PCDHB12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC3A2 grouped by PCDHB12-low versus PCDHB12-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB12→partner) and Y-score (partner→PCDHB12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC3A2 →	+0.538	+3.602	.005	.001	3	6
UCEC	PSPC1 →	+0.312	+2.284	.001	<.001	3	6
UCEC	MYO19 →	+0.400	+1.514	<.001	<.001	3	5
UCEC	POLE2 →	+0.493	+1.678	<.001	<.001	3	5
UCEC	CDKN3 →	+0.588	+1.667	<.001	<.001	3	5
UCEC	AAGAB →	+0.514	+2.180	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,923 associations by consensus.

SLC3A2 by PCDHB12 expression — HNSC

Explore this box plot interactively →