PCDHB12

Across TCGA patient cohorts, PCDHB12 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB12-associated genes across cancer lineages are GAPDH, ATM, and eIF4E. Each is linked with PCDHB12 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHB12-to-partner and partner-to-PCDHB12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PCDHB12-low versus PCDHB12-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB12→partner) and Y-score (partner→PCDHB12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.483	+2.008	.018	.018	3	4
UCEC	ATM →	-0.492	-1.765	<.001	<.001	3	4
UCEC	eIF4E →	+0.167	+2.598	.003	<.001	3	4
STAD	FASN →	+0.341	+1.890	.015	.028	3	3
STAD	PCNA →	+0.203	+3.321	.038	.008	3	3
STAD	Rictor_pT1135 →	-0.135	-1.765	.009	.012	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

GAPDH by PCDHB12 expression — COAD

Explore this box plot interactively →