PCDHB12

Across TCGA cell cohorts, PCDHB12 mutation is significantly associated with the RNA expression of many other genes, with 948 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHB12-associated genes across cancer lineages are CT45A8, MCCC2, and SOD1. Each is linked with PCDHB12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHB12-to-partner and partner-to-PCDHB12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CT45A8 grouped by PCDHB12-low versus PCDHB12-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB12→partner) and Y-score (partner→PCDHB12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CT45A8 →	+1.237	+3.866	<.001	.002	3	2
LARGE_INTESTINE	MCCC2 →	+0.469	+1.949	.004	.002	3	2
LARGE_INTESTINE	SOD1 →	+0.664	+3.130	<.001	<.001	3	2
LARGE_INTESTINE	PPARGC1B →	+0.741	+2.458	<.001	<.001	3	2
LARGE_INTESTINE	TNK1 →	+0.799	+2.764	<.001	<.001	3	2
LARGE_INTESTINE	OXCT2 →	+0.452	+2.005	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 948 associations by consensus.

CT45A8 by PCDHB12 expression — LUNG_SCLC

Explore this box plot interactively →