Across TCGA cell cohorts, PCDHB11 mutation is significantly associated with the RNA expression of many other genes, with 623 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHB11-associated genes across cancer lineages are RAP1GDS1, DCANP1, and KRTAP2-1. Each is linked with PCDHB11 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHB11-to-partner and partner-to-PCDHB11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB11→partner) and Y-score (partner→PCDHB11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RAP1GDS1 →	+0.788	+3.351	<.001	.003	3	3
OESOPHAGUS	DCANP1 →	+0.012	+4.392	<.001	.003	3	2
SOFT_TISSUE	KRTAP2-1 →	+0.115	+4.417	<.001	.004	3	2
BLOOD_Leukemia	APBA3 →	+0.599	+3.115	<.001	.009	3	2
BLOOD_Leukemia	HPCAL4 →	+0.167	+3.893	.001	<.001	3	2
BLOOD_Leukemia	ELOVL4 →	+2.101	+3.590	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 623 associations by consensus.

Exploration

PCDHB11 survival (RNA) · tumor vs normal (RNA) · all PCDHB11 data types