PCDHAC2

Across TCGA patient cohorts, PCDHAC2 mutation is significantly associated with the RNA expression of many other genes, with 2,507 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHAC2-associated genes across cancer lineages are LCEP1, FCER1A, and SULT1C4. Each is linked with PCDHAC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHAC2-to-partner and partner-to-PCDHAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCEP1 grouped by PCDHAC2-low versus PCDHAC2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHAC2→partner) and Y-score (partner→PCDHAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LCEP1 →	+0.069	+4.268	.001	.008	3	3
UCEC	FCER1A →	-0.660	-1.999	<.001	<.001	3	3
UCEC	SULT1C4 →	-0.820	-2.237	<.001	.001	3	3
UCEC	LRRC10B →	-1.131	-2.392	<.001	<.001	3	3
UCEC	SNAPC2 →	+0.326	+1.541	.005	.002	3	3
COAD	C1QBP →	+0.775	+3.584	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,507 associations by consensus.

LCEP1 by PCDHAC2 expression — BRCA

Explore this box plot interactively →