PCDHAC2

Across TCGA pan-cancer cohorts, PCDHAC2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PCDHAC2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where PCDHAC2 RNA is repressed in tumor relative to normal tissue. In most cancer types PCDHAC2 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, THCA, and KIRP are the cancer types where PCDHAC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCDHAC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−1.282	<.001	9	view →
THCA	Female	All	+0.711	<.001	6	view →
KIRP	All	III,IV	+0.550	.023	2	view →
LUAD	Female	All	−0.411	.009	2	view →
READ	All	All	−0.293	.014	2	view →
KIRC	All	All	+0.203	<.001	2	view →
KICH	All	All	−0.195	.012	1	view →
BRCA	Female	All	+0.092	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PCDHAC2–LUSC

Open the LUSC breakdown →