PCDHAC2

Across TCGA patient cohorts, PCDHAC2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHAC2-associated genes across cancer lineages are Caspase-8, MIG-6, and Notch1. Each is linked with PCDHAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHAC2-to-partner and partner-to-PCDHAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by PCDHAC2-low versus PCDHAC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHAC2→partner) and Y-score (partner→PCDHAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.222	-3.221	.006	<.001	3	2
COAD	MIG-6 →	+0.082	+1.749	.047	.049	3	2
UCEC	Notch1 →	+0.191	+3.013	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.606	+2.604	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.288	-1.716	<.001	.003	3	2
UCEC	Bcl-2 →	-0.230	-1.700	.041	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Caspase-8 by PCDHAC2 expression — UCEC

Explore this box plot interactively →