PCDHAC2

Across TCGA cell cohorts, PCDHAC2 mutation is significantly associated with the RNA expression of many other genes, with 951 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHAC2-associated genes across cancer lineages are ZNF518A, RWDD4, and FAM153CP. Each is linked with PCDHAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHAC2-to-partner and partner-to-PCDHAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF518A grouped by PCDHAC2-low versus PCDHAC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHAC2→partner) and Y-score (partner→PCDHAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF518A →	+0.892	+3.299	.001	.004	3	2
LARGE_INTESTINE	RWDD4 →	+0.566	+3.064	<.001	.009	3	2
LARGE_INTESTINE	FAM153CP →	+0.408	+3.761	<.001	.001	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BLOOD_Myeloma	UNCX →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C20orf141 →	+0.106	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 951 associations by consensus.

ZNF518A by PCDHAC2 expression — LARGE_INTESTINE

Explore this box plot interactively →