PCDHA6

Across TCGA patient cohorts, PCDHA6 mutation is significantly associated with the RNA expression of many other genes, with 6,342 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHA6-associated genes across cancer lineages are C4orf46, RBBP4, and NSD2. Each is linked with PCDHA6 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHA6-to-partner and partner-to-PCDHA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4orf46 grouped by PCDHA6-low versus PCDHA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA6→partner) and Y-score (partner→PCDHA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C4orf46 →	+0.470	+1.732	<.001	<.001	3	5
COAD	RBBP4 →	+0.293	+1.817	.002	.001	3	5
UCEC	NSD2 →	+0.361	+1.836	<.001	.001	3	4
UCEC	NCAPG →	+0.609	+2.496	<.001	<.001	3	4
UCEC	MDFI →	-0.660	-1.694	.002	.003	3	4
HNSC	MRPS27 →	+0.490	+3.221	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,342 associations by consensus.

C4orf46 by PCDHA6 expression — UCEC

Explore this box plot interactively →