Across TCGA patient cohorts, PCDHA5 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHA5-associated genes across cancer lineages are Cyclin-E2, 4E-BP1, and E-Cadherin. Each is linked with PCDHA5 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHA5-to-partner and partner-to-PCDHA5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA5→partner) and Y-score (partner→PCDHA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.109	+1.179	.035	.041	3	4
UCEC	4E-BP1 →	+0.245	+2.692	.003	<.001	3	3
LUAD	E-Cadherin →	-0.436	-1.874	.013	.047	3	2
UCEC	EGFR_pY1068 →	-0.235	-1.700	.002	.001	3	2
COAD	eIF4E →	+0.184	+1.832	.005	.015	3	2
UCEC	ERK2 →	+0.156	+1.263	.008	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Exploration

PCDHA5 survival (RNA) · tumor vs normal (RNA) · all PCDHA5 data types