Across TCGA cell cohorts, PCDHA5 mutation is significantly associated with the RNA expression of many other genes, with 922 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHA5-associated genes across cancer lineages are C8orf86, SLC25A28, and MROH2B. Each is linked with PCDHA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHA5-to-partner and partner-to-PCDHA5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA5→partner) and Y-score (partner→PCDHA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	C8orf86 →	+0.012	+3.606	.005	.002	3	2
SKIN	SLC25A28 →	+0.515	+3.212	.001	.006	3	2
SKIN	MROH2B →	+0.023	+2.639	<.001	.002	3	2
CNS	TDRD5 →	+0.463	+3.938	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.042	+4.357	<.001	.006	3	2
LARGE_INTESTINE	TNRC6B →	+0.723	+3.234	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 922 associations by consensus.

Exploration

PCDHA5 survival (RNA) · tumor vs normal (RNA) · all PCDHA5 data types