PCDHA3

Across TCGA patient cohorts, PCDHA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,006 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PCDHA3-associated GO terms across cancer lineages are Positive regulation of canonical Wnt signaling pathway, Post-Golgi vesicle-mediated transport, and Golgi organization. Each is linked with PCDHA3 in more than 25 cancer types. Because this analysis shows association rather than direction, both PCDHA3-to-partner and partner-to-PCDHA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of canonical Wnt signaling pathway grouped by PCDHA3-low versus PCDHA3-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA3→partner) and Y-score (partner→PCDHA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Positive regulation of canonical Wnt signaling pathway →	+0.061	+0.955	<.001	<.001	3	24
THYM	Post-Golgi vesicle-mediated transport →	+0.059	+0.147	<.001	.001	3	24
SCLC	Golgi organization →	+0.053	+0.970	.005	<.001	2	25
DLBC	Vacuole organization →	+0.045	+0.055	.008	<.001	1	26
THYM	Regulation of vacuole organization →	+0.070	+0.220	<.001	.004	2	25
TGCT	Regulation of autophagosome assembly →	+0.050	+0.256	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,006 associations by consensus.

Positive regulation of canonical Wnt signaling pathway by PCDHA3 expression — SCLC

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