PCDHA3

Across TCGA pan-cancer cohorts, PCDHA3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PCDHA3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PCDHA3 RNA is repressed in tumor relative to normal tissue. In most cancer types PCDHA3 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and UCEC are the cancer types where PCDHA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCDHA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.437	<.001	7	view →
KICH	Male	All	−0.850	<.001	6	view →
UCEC	All	All	−0.686	<.001	6	view →
LUSC	Female	II,III,IV	−0.557	<.001	6	view →
THCA	Female	All	+0.321	<.001	6	view →
BLCA	Male	IV	−0.315	.010	6	view →
LUAD	Female	All	−0.289	<.001	3	view →
STAD	All	All	−0.148	.040	3	view →
READ	All	All	−0.232	.004	2	view →
LIHC	All	All	+0.026	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PCDHA3–KIRC

Open the KIRC breakdown →