PCDHA3

Across TCGA cell cohorts, PCDHA3 mutation is significantly associated with the RNA expression of many other genes, with 334 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PCDHA3-associated genes across cancer lineages are GZMK, OSCP1, and PEX5. Each is linked with PCDHA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHA3-to-partner and partner-to-PCDHA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by PCDHA3-low versus PCDHA3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA3→partner) and Y-score (partner→PCDHA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GZMK →	+0.320	+2.844	.003	<.001	3	2
BLOOD_Leukemia	OSCP1 →	+0.802	+3.176	<.001	.008	3	2
BLOOD_Leukemia	PEX5 →	+0.913	+3.351	<.001	.003	3	2
BLOOD_Leukemia	FLG2 →	+0.073	+2.493	<.001	.003	3	2
BLOOD_Leukemia	SBK1 →	+1.608	+3.351	<.001	.003	3	2
BLOOD_Leukemia	USP17L7 →	+0.107	+3.059	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 334 associations by consensus.

GZMK by PCDHA3 expression — BLOOD_Leukemia

Explore this box plot interactively →