Across TCGA patient cohorts, PCDHA2 mutation is significantly associated with the RNA expression of many other genes, with 7,403 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHA2-associated genes across cancer lineages are METTL5, RER1, and NFYA. Each is linked with PCDHA2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHA2-to-partner and partner-to-PCDHA2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA2→partner) and Y-score (partner→PCDHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	METTL5 →	+0.365	+1.862	<.001	<.001	3	5
COAD	RER1 →	+0.221	+1.733	.002	.005	3	4
LUSC	NFYA →	+0.353	+2.495	.003	.009	3	4
LUSC	PMS1 →	+0.407	+2.271	<.001	.001	3	4
UCEC	MRPS27 →	+0.480	+1.713	<.001	<.001	3	4
UCEC	CCNG1 →	+0.421	+1.425	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,403 associations by consensus.

Exploration

PCDHA2 survival (RNA) · tumor vs normal (RNA) · all PCDHA2 data types