PCDHA13

Across TCGA patient cohorts, PCDHA13 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PCDHA13-associated genes across cancer lineages are eIF4E, ATM, and ASNS. Each is linked with PCDHA13 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDHA13-to-partner and partner-to-PCDHA13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PCDHA13-low versus PCDHA13-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA13→partner) and Y-score (partner→PCDHA13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	eIF4E →	+0.236	+3.000	.016	.028	3	5
UCEC	ATM →	-0.408	-1.638	<.001	.004	3	5
BRCA	ASNS →	+0.441	+3.000	.027	.038	3	4
READ	c-Kit →	-0.757	-3.000	.008	.028	3	4
LUAD	Caveolin-1 →	-0.735	-2.459	.027	.020	3	3
STAD	PCNA →	+0.226	+3.000	.040	.034	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

eIF4E by PCDHA13 expression — READ

Explore this box plot interactively →