PCDHA13

Across TCGA cell cohorts, PCDHA13 mutation is significantly associated with the mutation status of many other genes, with 6,216 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHA13-associated genes across cancer lineages are PI4KA, HELZ2, and FAM135A. Each is linked with PCDHA13 in more than 5 cancer types. Because this analysis shows association rather than direction, both PCDHA13-to-partner and partner-to-PCDHA13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI4KA grouped by PCDHA13-low versus PCDHA13-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA13→partner) and Y-score (partner→PCDHA13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PI4KA →	+3.718	+2.155	<.001	<.001	1	6
PANCREAS	HELZ2 →	+3.614	+3.321	.006	.006	1	6
PANCREAS	FAM135A →	+4.614	+3.672	.002	.002	1	6
BREAST	ADAM23 →	+4.807	+3.857	.002	.002	1	6
OVARY	SYNRG →	+3.930	+3.632	.003	.003	1	6
OVARY	PHF3 →	+3.345	+3.345	.007	.007	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,216 associations by consensus.

PI4KA by PCDHA13 expression — LARGE_INTESTINE

Explore this box plot interactively →