PCDHA12

Across TCGA patient cohorts, PCDHA12 mutation is significantly associated with the RNA expression of many other genes, with 5,571 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHA12-associated genes across cancer lineages are SUPV3L1, C12orf65, and GRPEL1. Each is linked with PCDHA12 in more than 5 cancer types. Because this analysis shows association rather than direction, both PCDHA12-to-partner and partner-to-PCDHA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUPV3L1 grouped by PCDHA12-low versus PCDHA12-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA12→partner) and Y-score (partner→PCDHA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SUPV3L1 →	+0.472	+3.050	<.001	<.001	3	6
BLCA	C12orf65 →	+0.391	+3.257	.007	.008	3	5
UCEC	GRPEL1 →	+0.349	+1.404	<.001	<.001	3	5
COAD	BLOC1S2 →	+0.337	+1.973	.002	.007	3	4
COAD	GPATCH3 →	+0.251	+1.791	.003	.001	3	4
COAD	NUDC →	+0.364	+3.080	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,571 associations by consensus.

SUPV3L1 by PCDHA12 expression — STAD

Explore this box plot interactively →