PCDHA12

Across TCGA pan-cancer cohorts, PCDHA12 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PCDHA12’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PCDHA12 RNA is repressed in tumor relative to normal tissue. In most cancer types PCDHA12 is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

KIRC, LUSC, and LUAD are the cancer types where PCDHA12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCDHA12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.019	<.001	12	view →
LUSC	Female	All	−1.318	<.001	7	view →
LUAD	Female	All	−0.855	<.001	6	view →
BRCA	Female	II,III,IV	+0.384	<.001	6	view →
KICH	Female	II,III,IV	−0.902	<.001	5	view →
THCA	All	II,III,IV	−0.656	<.001	5	view →
UCEC	All	All	−0.341	.002	4	view →
HNSC	All	II,III,IV	−0.120	.011	4	view →
READ	Male	All	−0.040	.025	4	view →
KIRP	Male	All	−0.613	.002	2	view →
PRAD	All	All	+0.201	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PCDHA12–KIRC

Open the KIRC breakdown →