PCDHA12

Across TCGA patient cohorts, PCDHA12 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHA12-associated genes across cancer lineages are eEF2, eIF4E, and PCNA. Each is linked with PCDHA12 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHA12-to-partner and partner-to-PCDHA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PCDHA12-low versus PCDHA12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA12→partner) and Y-score (partner→PCDHA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.270	+1.362	.003	.001	3	4
UCEC	eIF4E →	+0.185	+2.000	<.001	<.001	3	4
UCEC	PCNA →	+0.160	+1.222	.004	.003	3	4
COAD	Cyclin-E1 →	+0.280	+2.078	<.001	<.001	3	4
STAD	TIGAR →	+0.507	+3.169	.004	.017	3	3
STAD	CDK1 →	+0.373	+3.000	.012	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

eEF2 by PCDHA12 expression — UCEC

Explore this box plot interactively →