PCDHA12

Across TCGA cell cohorts, PCDHA12 mutation is significantly associated with the RNA expression of many other genes, with 277 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHA12-associated genes across cancer lineages are OR10J1, H1-0, and SFTPC. Each is linked with PCDHA12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHA12-to-partner and partner-to-PCDHA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10J1 grouped by PCDHA12-low versus PCDHA12-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA12→partner) and Y-score (partner→PCDHA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10J1 →	+0.566	+5.781	<.001	.001	3	2
LARGE_INTESTINE	H1-0 →	-1.115	-2.459	<.001	.003	3	2
BLOOD_Leukemia	SFTPC →	+0.054	+4.059	.004	<.001	3	2
BONE	OR8A1 →	+0.090	+5.169	<.001	.004	3	1
PANCREAS	TAAR8 →	+0.017	+4.614	<.001	.004	3	1
PANCREAS	H2AP →	+0.122	+4.491	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 277 associations by consensus.

OR10J1 by PCDHA12 expression — BREAST

Explore this box plot interactively →