PCDH8

Across TCGA cell cohorts, PCDH8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,937 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PCDH8-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Cytoplasmic translation, and Positive regulation of DNA recombination. Each is linked with PCDH8 in more than 7 cancer types. Because this analysis shows association rather than direction, both PCDH8-to-partner and partner-to-PCDH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by PCDH8-low versus PCDH8-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH8→partner) and Y-score (partner→PCDH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of gene expression, epigenetic →	+0.070	+0.576	<.001	.001	3	8
LUNG_SCLC	Cytoplasmic translation →	+0.058	+1.860	<.001	<.001	3	7
BONE	Positive regulation of DNA recombination →	+0.100	+2.925	<.001	<.001	3	6
BONE	Regulation of DNA repair →	+0.069	+2.310	<.001	.005	3	6
BONE	Positive regulation of cell junction assembly →	-0.096	-2.458	<.001	<.001	3	6
SOFT_TISSUE	Negative regulation of mRNA catabolic process →	+0.085	+1.010	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,937 associations by consensus.

Negative regulation of gene expression, epigenetic by PCDH8 expression — SOFT_TISSUE

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