PCDH8

Across TCGA pan-cancer cohorts, PCDH8 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated PCDH8 data layer compared with 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PCDH8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PCDH8 expression acts as an unfavorable survival marker, although some lineages such as UCS and UVM show a favorable association.

UCEC, UCS, and BLCA are the cancer types where PCDH8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	All	0.671	0.810	.001	68	view →
UCS	DFS	Tertile	II,III,IV	0.549	0.152	.007	46	view →
BLCA	OS	Median	All	0.545	0.652	.012	42	view →
KIRP	OS	Quartile	All	0.327	0.738	.001	33	view →
UVM	DFS	Median	III,IV	0.930	0.423	.003	31	view →
THCA	DFS	Quartile	All	0.781	0.937	.007	26	view →
COAD	DFS	Median	IV	0.653	0.338	.002	25	view →
KIRC	DFS	Median	All	0.906	0.862	.026	24	view →
ACC	DFS	Median	III,IV	0.721	0.245	<.001	24	view →
OV	DFS	Tertile	IV	0.446	0.201	.011	22	view →
TGCT	DFS	Quartile	All	0.579	0.935	.008	18	view →
LUSC	OS	Tertile	All	0.331	0.521	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

PCDH8–UCEC (OS)

Open the UCEC breakdown →