PCDH8

Across TCGA cell cohorts, PCDH8 mutation is significantly associated with the RNA expression of many other genes, with 2,031 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDH8-associated genes across cancer lineages are ATG4D, HAUS8, and ZIC5. Each is linked with PCDH8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDH8-to-partner and partner-to-PCDH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATG4D grouped by PCDH8-low versus PCDH8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH8→partner) and Y-score (partner→PCDH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ATG4D →	+0.638	+3.199	.006	.007	3	2
BLOOD_Leukemia	HAUS8 →	+0.611	+3.199	.001	.007	3	2
LARGE_INTESTINE	ZIC5 →	+0.982	+2.700	<.001	.001	3	2
LARGE_INTESTINE	H2AZ1 →	+0.604	+2.458	<.001	<.001	3	2
LARGE_INTESTINE	LRP5L →	+0.658	+2.458	.003	<.001	3	2
LARGE_INTESTINE	CUEDC2 →	+0.595	+3.764	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,031 associations by consensus.

ATG4D by PCDH8 expression — BLOOD_Leukemia

Explore this box plot interactively →