PCDH8

Across TCGA cell cohorts, PCDH8 mutation is significantly associated with the mutation status of many other genes, with 5,473 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDH8-associated genes across cancer lineages are AFF3, PLEKHA5, and WAPL. Each is linked with PCDH8 in more than 6 cancer types. Because this analysis shows association rather than direction, both PCDH8-to-partner and partner-to-PCDH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AFF3 grouped by PCDH8-low versus PCDH8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH8→partner) and Y-score (partner→PCDH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AFF3 →	+2.064	+1.773	.002	.002	1	7
OVARY	PLEKHA5 →	+4.467	+3.240	.004	.004	1	6
CNS	WAPL →	+6.044	+6.044	.001	.001	1	6
OVARY	EP300 →	+2.882	+2.882	.005	.005	1	6
BLOOD_Lymphoma	GLI3 →	+2.523	+2.874	.006	.006	1	5
OVARY	HIVEP2 →	+3.882	+3.345	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,473 associations by consensus.

AFF3 by PCDH8 expression — LARGE_INTESTINE

Explore this box plot interactively →