PCDH20

Across TCGA cell cohorts, PCDH20 mutation is significantly associated with the mutation status of many other genes, with 5,139 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDH20-associated genes across cancer lineages are ZFR, ADCY5, and GRIA2. Each is linked with PCDH20 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCDH20-to-partner and partner-to-PCDH20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZFR grouped by PCDH20-low versus PCDH20-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH20→partner) and Y-score (partner→PCDH20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZFR →	+4.584	+3.942	.002	.002	1	5
LARGE_INTESTINE	ADCY5 →	+2.807	+2.662	<.001	<.001	1	5
SOFT_TISSUE	GRIA2 →	+5.066	+4.502	.007	.007	1	5
PANCREAS	PARP9 →	+5.115	+5.115	.005	.005	1	4
BLOOD_Leukemia	RBM12 →	+4.894	+4.894	.004	.004	1	4
LUNG_NSCLC_LUAD	PCDHGA6 →	+3.396	+4.078	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,139 associations by consensus.

ZFR by PCDH20 expression — STOMACH

Explore this box plot interactively →